Scientometric Analysis of the Scientific Production on Hypoxanthine and Xanthine in Exercise, Published in Scopus Database (2016-2021)

Authors

Keywords:

physical exercise, hypoxanthine, xanthine, purines, scientific production, scientometrics.

Abstract

Hypoxanthine and xanthine are metabolic biomarkers that result from the degradation of purine proteins. Scientometric analyzes constitute a tool to study scientific publications around a certain topic in order to determine trends in the literature. A scientometric analysis was carried out of the recent scientific production on hypoxanthine and xanthine in exercise, published in Scopus database during the period 2016-2021. For the search in Scopus, we used the English keywords exercise, hypoxanthine and xanthine. A quantitative analysis was carried out, taking into account the articles found, as well as the information provided by VOSviewer software. Sixty-four articles were identified, 56 of them were applied research and eight were review. The exercise effect category had a larger number of studies (23). Here there is a subcategory of metabolism that had 21 articles. The United States and Poland are both the countries with the highest number of publications. There are different approaches and exercise protocols used to quantify the response of hypoxanthine and xanthine, as well as the profiles of the study subjects used as a sample for the investigations. The quantification of hypoxanthine and xanthine in the body is important for research in the field of exercise science.

Downloads

Download data is not yet available.

References

Finsterer J. Biomarkers of peripheral muscle fatigue during exercise. BMC Musculoskelet Disord. 2012;13:218. DOI: https://doi.org/10.1186/1471-2474-13-218

Lee EC, Fragala MS, Kavouras SA, Queen RM, Pryor JL, Casa DJ. Biomarkers in sports and exercise: Tracking health, performance, and recovery in athletes. J Strength Cond Res. 2017;31(10):2920-37. DOI: https://doi.org/10.1519/JSC.0000000000002122

Delsmann MM, Stürznickel J, Amling M, Ueblacker P, Rolvien T. Musculoskeletal laboratory diagnostics in competitive sport. Orthopade. 2021:1-11. DOI: https://doi.org/10.1007/s00132-021-04072-1

Nowakowska A, Kostrzewa-Nowak D, Buryta R, Nowak R. Blood biomarkers of recovery efficiency in soccer players. Int J Environ Res Public Health. 2019;16(18). DOI: https://doi.org/10.3390/ijerph16183279

Hoyos-Flores JR, Rangel-Colmenero BR, Alonso-Ramos ZN, García-Dávila MZ, Cruz-Castruita RM, Naranjo-Orellana J, et al. The Role of Cholinesterases in Post-Exercise HRV Recovery in University Volleyball Players. Appl Sci. 2021;11(9):4188. DOI: https://doi.org/10.3390/APP11094188

Wan JJ, Qin Z, Wang PY, Sun Y, Liu X. Muscle fatigue: General understanding and treatment. Exp Mol Med. 2017;49(10):e384. DOI: https://doi.org/10.1038/emm.2017.194

Egan B, Zierath JR. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17(2):162-84. DOI: https://doi.org/10.1016/j.cmet.2012.12.012

Hellsten-Westing Y, Balsom PD, Norman B, Sjodin B. The effect of high‐intensity training on purine metabolism in man. Acta Physiol Scand. 1993;149(4):405-12. DOI: https://doi.org/10.1111/j.1748-1716.1993.tb09636.x

Hellsten Y. The role of xanthine oxidase in exercise. En: Handbook of Oxidants and Antioxidants in Exercise. Elsevier; 2000:153-76. DOI: https://doi.org/10.1016/b978-044482650-3/50007-9

Sjodin B, Hellsten Westing Y. Changes in plasma concentration of hypoxanthine and uric acid in man with short-distance running at various intensities. Int J Sports Med. 1990;11(6):493-5. DOI: https://doi.org/10.1055/s-2007-1024844

Ipata PL, Pesi R. Metabolic interaction between purine nucleotide cycle and oxypurine cycle during skeletal muscle contraction of different intensities: a biochemical reappraisal. Metabolomics. 2018;14(4):42. DOI: https://doi.org/10.1007/s11306-018-1341-0

Dudzinska W, Lubkowska A, Dolegowska B, Safranow K, Jakubowska K. Adenine, guanine and pyridine nucleotides in blood during physical exercise and restitution in healthy subjects. Eur J Appl Physiol. 2010;110(6):1155-62. DOI: https://doi.org/10.1007/s00421-010-1611-7

Zieliński J, Kusy K. Training-induced adaptation in purine metabolism in high-level sprinters vs. triathletes. J Appl Physiol. 2012;112(4):542-51. DOI: https://doi.org/10.1152/japplphysiol.01292.2011

Kaya M, Moriwaki Y, Ka T, Inokuchi T, Yamamoto A, Takahashi S, et al. Plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine) and oxypurinol after rigorous exercise. Metabolism. 2006;55(1):103-7. DOI: https://doi.org/10.1016/j.metabol.2005.07.013

Hall IW. Report LXVIII. The relation of purin bodies to certain metabolic disorders. Br Med J. 1902;1(2163):1461-64. DOI: https://doi.org/10.1136/BMJ.1.2163.1461

Hargreaves M, Spriet LL. Skeletal muscle energy metabolism during exercise. Nat Metab. 2020;2(9):817-28. DOI: https://doi.org/10.1038/s42255-020-0251-4

Atamaniuk J, Vidotto C, Kinzlbauer M, Bachl N, Tiran B, Tschan H. Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise. Eur J Appl Physiol. 2010;110(4):695-701. DOI: https://doi.org/10.1007/s00421-010-1532-5

Włodarczyk M, Kusy K, Słomińska E, Krasiński Z, Zieliński J. Changes in Blood Concentration of Adenosine Triphosphate Metabolism Biomarkers during Incremental Exercise in Highly Trained Athletes of Different Sport Specializations. J Strength Cond Res. 2019;33(5):1192-200. DOI: https://doi.org/10.1519/JSC.0000000000003133

Zieliński J, Kusy K. Pathways of purine metabolism: effects of exercise and training in competitive athletes. TRENDS Sport Sci. 2015;3(22):103-12.

Domaszewska K, Szewczyk P, Kryściak J, Michalak E, Podgórski T. Purine metabolism in the light of aerobic and anaerobic capacity of female boxers. Cent Eur J Sport Sci Med. 2020;30(2):97-106. DOI: https://doi.org/10.18276/CEJ.2020.2-09

Włodarczyk M, Kusy K, Słomińska E, Krasiński Z, Zieliński J. Change in Lactate, Ammonia, and Hypoxanthine Concentrations in a 1-Year Training Cycle in Highly Trained Athletes: Applying Biomarkers as Tools to Assess Training Status. J Strength Cond Res. 2020;34(2):355-64. DOI: https://doi.org/10.1519/JSC.0000000000003375

Zieliński J, Kusy K. Hypoxanthine: A universal metabolic indicator of training status in competitive sports. Exerc Sport Sci Rev. 2015;43(4):214-21. DOI: https://doi.org/10.1249/JES.0000000000000055

Quintas G, Reche XJ, Sanjuan-Herráez D, Martínez H, Herrero M, Valle X et al. Urine metabolomic analysis for monitoring internal load in professional football players. Metabolomics. 2020;16(45). DOI: https://doi.org/10.1007/s11306-020-01668-0

Linnenluecke MK, Marrone M, Singh AK. Conducting systematic literature reviews and bibliometric analyses: Aust J Manag. 2020;45(2):175-94. DOI: https://doi.org/10.1177/0312896219877678

Scopus. What is Scopus about? - Scopus: Access and use Support Center. Publicado en 2021. [acceso 01/11/2021]. Disponible en: https://service.elsevier.com/app/answers/detail/a_id/15100/supporthub/scopus/

Published

2023-05-02

How to Cite

1.
Bouché-González F, Hernández-Cruz G, García-Dávila MZ, Rangel-Colmenero BR. Scientometric Analysis of the Scientific Production on Hypoxanthine and Xanthine in Exercise, Published in Scopus Database (2016-2021). Rev. cuba. inf. cienc. salud [Internet]. 2023 May 2 [cited 2025 Mar. 16];34. Available from: https://acimed.sld.cu/index.php/acimed/article/view/2129

Issue

Section

Artículos Originales